Radioimmuno assay for erythromycin derivatives.
نویسندگان
چکیده
منابع مشابه
Epimerization of erythromycin derivatives.
Dirithromycin (3) isomerizes upon dissolution in different solvents. From X-ray analysis of V-T 108, an analogue of dirithromycin, and comparative 1H and 13C NMR, and MS data, the isomer of dirithromycin was confirmed to be the C-16-(S)-epimer. The ratio of the two epimers at equilibrium conditions was approximately 8:2 (R/S) in methanol at room temperature.
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To the Editor: It was disturbing to read the article entitled “Studies of the Stability of 18 Chemical Constituents,” in the December, 1972, issue of Clinical Chemistry (1). The authors define their conditions of collection and storage but do not, however, make it clear what their object is. If the objective was to show stability of serum before analysis, then their data are misleading. For exa...
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A chemical assay method which depends upon the development of intense absorption at 485 nm has been found satisfactory for the assay of erythromycin and its stearate from tablets, suspensions and other preparations. Its utility is brevokable for the determination of this antibiotic at all stages of manufacture, process and formulation, and it is more rapid and reproducible than the bioassay (JP...
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The methylmalonyl coenzyme A (methylmalonyl-CoA)-specific acyltransferase (AT) domains of modules 1 and 2 of the 6-deoxyerythronolide B synthase (DEBS1) of Saccharopolyspora erythraea ER720 were replaced with three heterologous AT domains that are believed, based on sequence comparisons, to be specific for malonyl-CoA. The three substituted AT domains were "Hyg" AT2 from module 2 of a type I po...
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A previously unknown chemical structure, 6-desmethyl-6-ethylerythromycin A (6-ethylErA), was produced through directed genetic manipulation of the erythromycin (Er)-producing organism Saccharopolyspora erythraea. In an attempt to replace the methyl side chain at the C-6 position of the Er polyketide backbone with an ethyl moiety, the methylmalonate-specific acyltransferase (AT) domain of the Er...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1988
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.41.258